Clinical Case Reports and New mNGS-Based Technologies

Name: Clinical Case Reports and New mNGS-Based Technologies
Uploaded: 2019-06-24T00:00:00+00:00
Description: Charles Chiu, MD, PhD, discusses cases where mNGS testing saved the life of a patient with undiagnosed neuroleptospirosis, and spared another patient from a potentially unnecessary liver transplant.

Charles Chiu, MD, PhD, discusses cases where mNGS testing saved the life of a patient with undiagnosed neuroleptospirosis, and spared another patient from a potentially unnecessary liver transplant. He also explains the advantages of machine learning-based analysis of RNA sequencing data and nanopore sequencing, an emerging approach for rapid, real-time analysis of mNGS data to potentially diagnose infections within hours and within the point-of-care setting.

Read The New England Journal of Medicine paper Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

Learn more about the UCSF Center for Next-Gen Precision Diagnostics (NGDx).

Published

June 24, 2019

Created by

Related Presenters

Charles Chiu, MD

Internist

View Full Profile

Related Videos

Video

Brain Aneurysms: What Primary Care Providers Need to Know

This presentation from neurosurgeon Ethan A. Winkler, MD, PhD, offers data-driven guidelines on assessing a patient's risk, covering factors that range from alcohol consumption and family history to the location, size and shape of the aneurysm.

Video

Assessing Cognitive Decline in Primary Care: New Tools and Algorithms for Everyday Practice

Although timely diagnosis can significantly improve a patient’s future, dementia is underdiagnosed and often detected late.

Video

Slumber Secrets: New Insights into the Complexities of Sleep and Managing Common Issues

Sleep medicine specialist Rochelle Zak, MD, delivers a rousing update on what’s known about sleep’s stages and physiological payoffs, followed by her guide to assessing and treating insomnia – by far the main sleep issue seen in primary care.

Video

Assessing First Seizures: Steps for Primary Care Providers

Neurologist Manu Hegde, MD, PhD, breaks seizures into basic classes and puts the numerous epilepsy syndromes into three useful categories. He discusses how to take better histories; what to check for during physical exams; and what to ...

Video

The Value of Focused Ultrasound for Essential Tremor: Safety, Precision, Sustained Results

The most common movement disorder, essential tremor often doesn’t respond to meds and depresses quality of life. As neurosurgeon Doris Wang, MD, PhD, explains in this short, information-packed presentation, focused ultrasound can bring ...

Video

Sudden, Severe Headaches: Responding to the Thunderclap

Extreme headache pain that comes on abruptly (the “thunderclap”) can signal a number of serious conditions – such as subarachnoid hemorrhage – or have a simple cause such as sexual activity or a change in medication.

Video

Sleepy Patients: Identify and Treat Common Sleep Disorders

David Claman, MD, director of the UCSF Sleep Disorders Center, presents an update on the sleep problems often seen in primary care, from insomnia to restless legs syndrome to obstructive sleep apnea.

Video

Headache Help: Making Sense of Migraines and a Multitude of Therapies

Neurologist Morris Levin, MD, director of the UCSF Headache Center, reviews the diagnostic criteria for migraines and other headaches, followed by a breakdown of preventive and acute treatments.

Video

Look Beyond Symptoms: When to Test for Pituitary Tumors

Tumors of the body’s “master gland” cause various symptoms – headaches, depression, sexual dysfunction, vision loss – that doctors often attribute to other conditions. UCSF endocrinology and neurosurgery specialists discuss keys to identifying ...